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quinupristin/dalfopristin will enhance the amount or effect of ivacaftor by affecting hepatic/intestinal enzyme CYP3A4 metabolism.quinupristin/dalfopristin will boost the amount or result of donepezil by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Significance Not known.quinupristin/dalfopristin will improve the amount or impact of